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Primary Aldosteronism and Obstructive Sleep Apnea: Is This A Bidirectional Relationship?
Aleksander Prejbisz1, Sylwia Kołodziejczyk-Kruk1, Jacques W M Lenders2,3
1Department of Hypertension, Institute of Cardiology, Warsaw, Poland.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|December 5, 2017
Summary
Obstructive sleep apnea (OSA) and primary aldosteronism (PA) are linked in resistant hypertension (RHT). Treating PA may improve OSA, and treating OSA may lower aldosterone levels, suggesting a bidirectional relationship.
Area of Science:
- Endocrinology
- Cardiology
- Sleep Medicine
Background:
- Resistant hypertension (RHT) frequently co-occurs with obstructive sleep apnea (OSA).
- Primary aldosteronism (PA) is highly prevalent in RHT patients.
- A potential bidirectional relationship between aldosterone and OSA has been hypothesized.
Purpose of the Study:
- To explore the intricate relationship between aldosterone and OSA in patients with RHT.
- To investigate the impact of aldosterone on OSA severity and vice versa.
Main Methods:
- Observational studies correlating aldosterone levels with OSA severity in RHT.
- Studies examining the effect of aldosterone blockade on OSA.
- Research investigating PA prevalence in OSA patients.
- Studies assessing the influence of OSA treatment on aldosterone levels.
Main Results:
- Aldosterone levels correlate with OSA severity in RHT patients.
- Aldosterone blockade has been shown to reduce OSA severity.
- PA is more common in OSA patients, and PA treatment improves OSA.
- OSA patients exhibit higher aldosterone levels and PA prevalence; OSA treatment may decrease aldosterone.
Conclusions:
- A significant link exists between aldosterone and OSA, particularly in RHT.
- The relationship appears bidirectional, with implications for patient management.
- Screening hypertensive patients with OSA for PA is recommended.
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