Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 17, 2026

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

1.5K

A Comparative Assessment of Implant Site Viability in Humans and Rats.

C-H Chen1,2, X Pei2,3, U S Tulu2

  • 11 Craniofacial Research Center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan.

Journal of Dental Research
|December 6, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epithelial Rests of Malassez Form a Wnt-Dependent Mechanoresponsive Network.

Journal of dental research·2026
Same author

Injury-Activated ERMs Undergo EMT and May Contribute to Periodontal Repair.

Journal of dental research·2025
Same author

BMP/WNT-Dependent Mechanisms of Junctional Epithelium Turnover.

Journal of dental research·2025
Same author

The Junctional Epithelium Attachment Is Regulated by Wnt Signaling.

Journal of dental research·2025
Same author

Multidimensional benefits of olfactory training for chronic COVID-19-related olfactory dysfunction: a systematic review and meta-analysis.

Rhinology·2025
Same author

Erratum: Centrality-Dependent Modification of Jet-Production Rates in Deuteron-Gold Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 116, 122301 (2016)].

Physical review letters·2025

This study developed an osteopenic rat model to investigate osteotomy site preparation for dental implants. Findings show drilling causes osteocyte death, but bone regeneration occurs, suggesting improved techniques can enhance implant osseointegration.

Area of Science:

  • Biomaterials Science
  • Oral and Maxillofacial Surgery
  • Regenerative Medicine

Background:

  • Osteotomy site preparation is critical for dental implant success.
  • Osteoporotic bone conditions, common in implant patients, pose challenges.
  • Standardized models are needed to study bone healing after osteotomy.

Purpose of the Study:

  • To develop and validate a rat model for studying oral osteotomy site preparation.
  • To compare human and rat alveolar bone responses to osteotomy.
  • To identify strategies for improving implant osseointegration.

Main Methods:

  • Created an oral osteotomy model in ovariectomized rats with an osteopenic phenotype.
  • Produced osteotomies in healed extraction sites using commercial drills.
Keywords:
bonecomputer modeldrillosteogenesisosteotomyovariectomy

More Related Videos

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:37

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

95
An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

15.9K

Related Experiment Videos

Last Updated: Feb 17, 2026

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

1.5K
Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:37

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

95
An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

15.9K
  • Analyzed molecular, cellular, and histologic responses in both rats and human patients.

    • Main Results:

    • The rat model closely mimicked human alveolar bone response to osteotomy.
    • Drilling created a zone of osteocyte death in both humans and rats.
    • Osteoclast-mediated resorption of necrotic bone stimulated new bone formation by osteoblasts within a week.

    Conclusions:

    • The ovariectomy rat model is suitable for studying human bone response to osteotomy.
    • Reducing osteocyte death during drilling may enhance osteotomy site viability.
    • Improved osteotomy preparation can accelerate new bone formation and implant osseointegration.