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Precision medicine for HIV: where are we?
Jessica Cusato1, Sarah Allegra1, Amedeo De Nicolò1
1Department of Medical Sciences; University of Turin - ASL 'Città di Torino' Laboratory of Clinical Pharmacology and Pharmacogenetics; Amedeo di Savoia Hospital, Turin, Italy.
Pharmacogenomics
|December 6, 2017
Summary
Personalizing antiretroviral therapy for HIV patients improves long-term efficacy and reduces adverse events. Tailored treatment plans, considering individual factors, are key for better HIV/AIDS management.
Area of Science:
- Infectious Diseases
- Pharmacology
- Immunology
Background:
- Antiretroviral therapy (ART) is effective for HIV, but lifelong treatment necessitates personalization.
- Individual patient factors can influence ART effectiveness and safety.
Purpose of the Study:
- To review key factors influencing the personalization of antiretroviral treatment for HIV-positive patients.
- To highlight the importance of tailored ART regimens for optimized patient outcomes.
Main Methods:
- Literature search of English articles via PubMed.
- Inclusion of abstracts from recent congresses.
Main Results:
- Key factors include pharmacodynamics, drug monitoring, pharmacogenetics, comorbidities, immune status, and viral characteristics.
- Pharmacoeconomic aspects are also considered.
- Pharmacokinetic and pharmacogenetic data can guide treatment selection for efficacy and safety.
Conclusions:
- Personalized antiretroviral therapy holds promise for improved long-term HIV management.
- Further randomized trials are needed to confirm the clinical utility of tailored ART regimens.
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