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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
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Bioengineering considerations in liver regenerative medicine.

Ogechi Ogoke1,2, Janet Oluwole2,3, Natesh Parashurama1,2,3

  • 1Department of Chemical and Biological Engineering, University at Buffalo (State University of New York), Furnas Hall, Buffalo, NY 14260 USA.

Journal of Biological Engineering
|December 6, 2017
PubMed
Summary

Liver regenerative medicine offers innovative solutions to combat the growing burden of liver disease. This field explores diverse approaches, including cell therapies and bioengineering, to improve patient outcomes.

Keywords:
Adult liver stem cell/progenitor cellsBioartificial liverDecellularized liver graftsHepatocyte transplantationHepatoxicity and engineered devicesLiver cell therapiesLiver regenerationLiver transplantationMouse liver repopulationPluripotent stem cellsPrimary hepatocyte cell culture

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Area of Science:

  • Regenerative Medicine
  • Bioengineering
  • Hepatology

Background:

  • Liver disease poses a significant global health challenge with increasing incidence and costs.
  • Innovative strategies are needed to address the rising burden of liver disease.
  • Liver regenerative medicine presents a promising frontier for novel therapeutic interventions.

Purpose of the Study:

  • To provide a comprehensive overview of liver regenerative medicine.
  • To discuss the history, progress, and commercialization of key subfields.
  • To highlight the interdisciplinary nature of liver regenerative medicine.

Main Methods:

  • Review of fundamental aspects of liver transplantation and regeneration.
  • Exploration of primary hepatocyte cell culture and bioartificial liver devices.
  • Analysis of cell-based therapies including hepatocyte transplantation, stem cell applications, and decellularized liver grafts.
  • Discussion of hepatic microdevices and mouse liver repopulation models.

Main Results:

  • Liver regenerative medicine encompasses diverse and rapidly advancing subfields.
  • Significant progress has been made in areas such as stem cell therapies and bioengineered liver constructs.
  • Commercialization efforts are underway across various liver regenerative medicine applications.

Conclusions:

  • Liver regenerative medicine is characterized by creative research directions and collaborative efforts.
  • A bright outlook exists for a wide range of approaches impacting patients with liver disease.
  • Interdisciplinary collaboration among scientists, engineers, and clinicians is crucial for advancing the field.