Related Experiment Video

Updated: Feb 17, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.3K

The current status of oncolytic viral therapy for head and neck cancer

Matthew O Old1, Trisha Wise-Draper2, Chadwick L Wright3

  • 1Department of Otolaryngology - Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center at The Ohio State University, USA.

World Journal of Otorhinolaryngology - Head and Neck Surgery
|December 6, 2017
PubMed
Abstract

Insights

Oncolytic virus therapy shows promise for head and neck cancers. Ongoing research and clinical trials are advancing this treatment approach for improved patient outcomes.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy

Background:

  • Head and neck cancers present significant morbidity and mortality.
  • Oncolytic viral therapy offers a promising avenue for treating these challenging cancers.

Purpose of the Study:

  • To review the current landscape of oncolytic virus applications in head and neck cancer treatment.
  • To assess the progress and future potential of oncolytic virotherapy in this field.

Main Methods:

  • Comprehensive literature review.
  • Analysis of data from national clinical trials databases.
  • Inclusion of current research findings.

Main Results:

  • Numerous clinical trials, both completed and ongoing, demonstrate the potential of oncolytic viruses against head and neck cancers.
  • The U.S. Food and Drug Administration (FDA) approved the first oncolytic virus (T-VEC) in October 2015 for melanoma treatment.
  • Active translational research is underway for T-VEC and other oncolytic virus agents.

Conclusions:

  • The field of oncolytic virotherapy is rapidly evolving and significantly impacting head and neck cancer treatment paradigms.
  • Advancements in oncolytic virus agents and further clinical trials are anticipated in the near future.
Keywords:
Clinical trialsHead and neck squamous cell carcinomaNovel therapeuticsOncolytic viruses

More Related Videos

Ex Vivo Infection of Live Tissue with Oncolytic Viruses12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

13.4K
Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus06:14

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

Published on: May 13, 2021

7.5K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
621