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Updated: Feb 17, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
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Dynamic swallowing study for globus patients.

Jinrang Li1, Jie Zhang1, Pengfei Guo1

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Navy General Hospital, Beijing, 100048, China.

World Journal of Otorhinolaryngology - Head and Neck Surgery
|December 6, 2017
PubMed
Summary
This summary is machine-generated.

Globus patients experiencing swallowing difficulty do not show impaired pharyngeal swallowing function. Dynamic swallowing studies revealed no significant differences in key swallowing parameters compared to healthy adults.

Keywords:
Dynamic swallowing studyGlobusPharynxSwallowing function

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Area of Science:

  • Otolaryngology
  • Gastroenterology
  • Neurology

Background:

  • Globus pharyngeus, commonly known as globus sensation, is characterized by the subjective feeling of a lump in the throat.
  • Patients often report associated swallowing difficulties, prompting investigation into underlying physiological impairments.
  • The precise mechanisms and physiological basis of swallowing difficulties in globus patients remain incompletely understood.

Purpose of the Study:

  • To objectively assess pharyngeal swallowing function in patients diagnosed with globus pharyngeus and experiencing dysphagia.
  • To determine if objective measures of swallowing physiology differ between globus patients and healthy individuals.
  • To investigate the role of dynamic swallowing studies in evaluating the pharyngeal swallowing mechanism in this patient population.

Main Methods:

  • Dynamic swallowing studies were conducted on 33 globus patients with reported swallowing difficulties and 80 healthy adult volunteers.
  • Key objective parameters of pharyngeal swallowing function were measured, including hyoid bone displacement, pharyngeal transit time, pharyngeal constriction ratio, and esophageal entrance opening.
  • Statistical analysis was performed to compare these parameters between the globus patient group and the control group.

Main Results:

  • No statistically significant differences were observed between globus patients and normal adults in maximum hyoid bone displacement (p > 0.05).
  • Pharyngeal transit time, pharyngeal constriction ratio, and maximum opening of the esophageal entrance showed no significant variations between the two groups (p > 0.05).
  • These objective findings suggest preserved pharyngeal swallowing mechanics in globus patients.

Conclusions:

  • The dynamic swallowing study results indicate that globus patients with swallowing difficulty do not exhibit impaired pharyngeal swallowing function.
  • Objective physiological assessment via dynamic swallowing studies does not support a diagnosis of physical pharyngeal dysfunction in globus sensation.
  • Further research may explore other contributing factors to the sensation of difficulty in swallowing among globus patients.