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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Peripheral Leptin Signaling Mediates Formalin-Induced Nociception.

Zhi-Jing Hu1,2, Wei Han2, Chang-Qing Cao2

  • 1Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences; Institutes of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Institute of Acupuncture and Moxibustion, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai, 200032, China.

Neuroscience Bulletin
|December 6, 2017
PubMed
Summary

Obesity does not affect acute thermal pain but reduces inflammatory pain responses. Leptin signaling is impaired in obesity, suggesting leptin receptor pathway interference as a target for acute inflammatory pain relief.

Keywords:
Formalin testLeptinNociceptionObesity

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