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Related Concept Videos

Human Genetics01:28

Human Genetics

1.7K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.7K
Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: Feb 17, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

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"Genetic code" of brain ageing.

Pentti Tienari, Liisa Myllykangas

    Duodecim; Laaketieteellinen Aikakauskirja
    |December 6, 2017
    PubMed
    Summary

    Brain ageing impacts neurons due to their high energy needs and inability to divide. Genetic factors influencing Alzheimer's disease, vascular diseases, and metabolism are key to understanding brain ageing and longevity.

    Area of Science:

    • Neuroscience
    • Genetics
    • Metabolism

    Background:

    • Neurons are highly susceptible to ageing due to limited replication and high energy demands.
    • Genes regulating Alzheimer's and vascular disease risk are central to brain ageing.
    • Genetic factors are implicated in memory disorders and longevity.

    Purpose of the Study:

    • To explore the genetic underpinnings of brain ageing.
    • To identify key genes and metabolic pathways involved in neuronal ageing.
    • To understand the influence of lifestyle and social factors on brain ageing genetics.

    Main Methods:

    • Analysis of genetic studies related to brain ageing.
    • Investigation of genes associated with Alzheimer's disease and vascular conditions.

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  • Examination of metabolic routes, including fat and energy metabolism.

    • Main Results:

    • Identified a "genetic code of brain ageing" involving specific genes.
    • Highlighted the role of fat and energy metabolism in brain ageing.
    • Found that lifestyle and social structures can influence these genetic pathways.

    Conclusions:

    • Neuronal ageing is significantly influenced by genetic factors.
    • Metabolic pathways and lifestyle choices interact with genetics to affect brain health.
    • Understanding these genetic and metabolic interactions is crucial for promoting longevity and cognitive function.