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A hemin auxotrophic Enterobacter cloacae clinical isolate with increased resistance to carbapenems and
Tatsuya Tada1,2, Kohei Uechi3,4, Isamu Nakasone5
1Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan.
Abstract:
Small-colony variants (SCVs) were obtained from an Enterobacter cloacae clinical isolate in Okinawa, Japan. One variant showed auxotrophy for hemin with a deletion of 20 365 nucleotides, dosC-ydiK-mmuP-mmuM-tauA-tauB-tauC-tauD-hemB-yaiT-yaiV-ampH-yddQ-sbmA-yaiW-yaiY-yaiZ, including hemB, and was more resistant to aminoglycosides and carbapenems, but more susceptible to aztreonam, than the parent strain.
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