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Jack Aviv and brains of children

Angelo A Lamola1

  • 1Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California.

Biopolymers
|December 6, 2017
PubMed

Insights

Early childhood lead intoxication and low bilirubin-binding capacity in newborns pose brain damage risks. Hematofluorometry offers rapid, cost-effective blood tests for zinc protoporphyrin and bilirubin-binding capacity, aiding neurotoxicity assessment.

Area of Science:

  • Biomedical Engineering
  • Clinical Chemistry
  • Neonatology

Background:

  • Lead intoxication in children and deficient bilirubin-binding capacity (BBC) in jaundiced neonates are critical risk factors for brain damage.
  • Zinc protoporphyrin (ZPP) serves as a key biomarker for both lead intoxication (PbI) and iron deficiency.

Discussion:

  • Aviv Biomedical, Inc. developed advanced hematofluorometers for point-of-care testing of ZPP and BBC in blood.
  • These assays require minimal blood samples, offering simplicity, speed, and affordability.

Key Insights:

  • Hematofluorometry for ZPP has been a global standard for lead intoxication screening since 1979.
  • Recent studies highlight the utility of BBC assessment using hematofluorometry for managing neonatal jaundice and neurotoxicity.

Outlook:

  • Further application of hematofluorometry can enhance neurotoxicity assessment in neonates.
  • Continued development and utilization of these point-of-care tools promise improved diagnostic capabilities in clinical settings.

Keywords:
Avivbilirubin bindinghematofluorometrylead intoxicationneonatal jaundice

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