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Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene
Lingling Zhang1,2,3,4, Xiang Wen1, Mengmeng Li1
1Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Abstract:
In past decades, increasing evidence regarding cancer stem cells (CSCs) may account for carcinogenesis, tumor drug-resistant, and metastasis. CSCs are even considered as the root causes of tumor recurrence and metastases. Targeting CSCs may provide a new clue to cure cancer. Epidemiological and clinical studies have suggested that intake of dietary natural products may bring health benefits including lowering risk of cancer incidence. In this review, we have particularly focused on targeting signaling pathways of CSCs by natural resveratrol and its dimethylated derivative pterostilbene. © 2017 BioFactors, 44(1):61-68, 2018.
Insights
Natural compounds like resveratrol and pterostilbene show promise in targeting cancer stem cells (CSCs), which drive tumor growth, resistance, and metastasis. This review explores their potential to combat cancer recurrence and improve treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Natural Product Chemistry
Background:
- Cancer stem cells (CSCs) are implicated in tumor initiation, drug resistance, metastasis, and recurrence.
- Dietary natural products have shown potential health benefits, including cancer risk reduction.
- Targeting CSCs represents a promising strategy for novel cancer therapies.
Purpose of the Study:
- To review the role of natural compounds, specifically resveratrol and pterostilbene, in targeting cancer stem cell signaling pathways.
- To explore the therapeutic potential of these natural products in overcoming cancer drug resistance and metastasis.
Main Methods:
- Literature review focusing on studies investigating resveratrol and pterostilbene.
- Analysis of signaling pathways targeted by these compounds in cancer stem cells.
- Examination of epidemiological and clinical data on dietary natural products and cancer risk.
Main Results:
- Resveratrol and pterostilbene, natural compounds, exhibit potential in targeting key signaling pathways crucial for CSC survival and function.
- These compounds may offer a novel approach to combatting tumor drug resistance and metastasis driven by CSCs.
- Evidence suggests a link between dietary natural products and reduced cancer incidence.
Conclusions:
- Resveratrol and pterostilbene are promising candidates for developing new cancer therapies that target cancer stem cells.
- Further research into these natural compounds could lead to innovative strategies for preventing and treating cancer recurrence and metastasis.
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