Changing brain connectivity dynamics: From early childhood to adulthood
Ashkan Faghiri1,2, Julia M Stephen1, Yu-Ping Wang3,4
1The Mind Research Network, 1101 Yale Blvd NE, Albuquerque, New Mexico.
Human Brain Mapping
|December 6, 2017
Summary
As children mature, their brain
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Brain Imaging
Background:
- Adolescent brain development involves changes in structure and function.
- Previous research often focused on static functional connectivity.
- Dynamic functional connectivity during development remains less explored.
Purpose of the Study:
- To investigate the relationship between age and the dynamics of functional brain connectivity.
- To understand how brain functional connectivity changes over time during development.
Main Methods:
- Utilized resting-state fMRI data from 421 participants (ages 3-22) from the PING study.
- Applied group Independent Component Analysis (ICA) to extract components and time courses.
- Calculated dynamic functional network connectivity (dFNC) using a sliding window approach and clustered patterns into 5 states.
Main Results:
- Older participants spent more time in brain states characterized by stronger overall connectivity.
- Age-related transitions among connectivity states exhibited a symmetric pattern.
- Individual functional connectivity dynamics evolve within a defined set of states over time.
Conclusions:
- Dynamic functional connectivity is crucial for understanding brain development across childhood and adolescence.
- Brain maturation involves shifts in the dynamic patterns of functional connectivity.
- The study highlights the importance of considering temporal dynamics in brain development research.
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