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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Enantioselective Photochemical Organocascade Catalysis
Łukasz Woźniak1, Giandomenico Magagnano1, Paolo Melchiorre2,1
1ICIQ-Institute of Chemical Research of Catalonia, The Barcelona Institute of Science and Technology, Avenida Països Catalans 16, 43007, Tarragona, Spain.
Abstract:
Reported herein is a photochemical cascade process that combines the excited-state and ground-state reactivity of chiral organocatalytic intermediates. This strategy directly converts racemic cyclopropanols and α,β-unsaturated aldehydes into stereochemically dense cyclopentanols with exquisite stereoselectivity. Mechanistic investigations have enabled elucidating the origin of the stereoconvergence, which is governed by a kinetic resolution process.
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