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Related Experiment Video

Updated: Jul 20, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

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Published on: October 16, 2013

Colonoscopy conversion after flexible sigmoidoscopy screening: results from the UK Bowel Scope Screening Programme.

K Siau^1,2, A C Yew³, S Ishaq^2,4

¹Joint Advisory Group on Gastrointestinal Endoscopy (JAG), Royal College of Physicians, London, UK.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland

|December 6, 2017

Summary

In the UK Bowel Scope Screening Programme, male gender and polyps ≥10mm found during flexible sigmoidoscopy (FS) predict additional adenomas during colonoscopy. These findings may inform future screening criteria adjustments.

Keywords:

Bowel cancer colonoscopy screening

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Area of Science:

Gastroenterology
Public Health
Oncology

Background:

The UK Bowel Scope Screening Programme (BSSP) uses flexible sigmoidoscopy (FS) to identify high-risk patients for subsequent colonoscopy.
Assessing the effectiveness of colonoscopy conversion criteria and identifying predictors of additional adenoma detection is crucial for optimizing screening pathways.

Purpose of the Study:

To evaluate the practice of colonoscopy conversion following FS within the BSSP.
To identify predictors for the detection of additional adenomas during colonoscopy after initial FS.

Main Methods:

A retrospective analysis of the Bowel Cancer Screening database, including endoscopic and histological findings from patients undergoing colonoscopy post-FS (August 2013 - August 2016).
Multivariate analysis was employed to determine predictors of new adenoma detection.

Main Results:

Out of 11,711 FS procedures, 421 (3.6%) converted to colonoscopy with an additional adenoma detection rate (ADR) of 35.2%.
Male gender and polyps ≥10mm detected during FS were significant predictors of additional adenomas (≥10mm) found during colonoscopy.
Villous histology, polyp size ≥10mm, and male gender predicted new adenomas ≥10mm; any conversion criterion predicted proximal adenomas and those ≥10mm.

Conclusions:

Male gender, larger polyps (≥10mm), and villous histology during FS are key predictors for adenomas found during subsequent colonoscopy.
Further research is needed to explore gender-based stratification of colonoscopy conversion criteria in screening programs.