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Updated: Feb 17, 2026

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Published on: May 31, 2012

The Human Cell Atlas.

Aviv Regev^1,2,3, Sarah A Teichmann^4,5,6, Eric S Lander^1,2,7

¹Broad Institute of MIT and Harvard, Cambridge, United States.

|December 6, 2017

Summary

This summary is machine-generated.

The Human Cell Atlas Project aims to map all human cell types using molecular profiles. This initiative will create a comprehensive reference for studying health, development, and disease.

Keywords:

cell atlas cell biology computational biology human lineage mouse science forum single-cell genomics systems biology

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Area of Science:

Genomics
Cell Biology
Bioinformatics

Background:

High-throughput single-cell molecular profiling technologies have advanced significantly.
There is a growing scientific consensus to complete the 150-year-old goal of identifying all human cell types.

Purpose of the Study:

To define all human cell types by their unique molecular profiles.
To integrate molecular data with classical cellular descriptions (location, morphology).
To create an open reference map of healthy human cells.

Main Methods:

Utilizing high-throughput single-cell molecular profiling.
Analyzing gene expression profiles.
Connecting molecular data with cellular location and morphology.

Main Results:

Early proof-of-concept studies demonstrate feasibility.
Development of design considerations for the Human Cell Atlas.
Establishment of a commitment to open data, code, and community.

Conclusions:

The Human Cell Atlas will accelerate the study of physiological states and developmental trajectories.
It will provide a framework for understanding cellular dysregulation in human diseases.
An open and collaborative approach is central to the project's success.