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Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects.

Shijie Deng1, Peng Wang2, Xinglong Yu3

  • 1State Key Laboratory of Precision Measurement Technology and Instruments, Tsinghua University, Beijing 100084, China. dengshijie@mail.tsinghua.edu.cn.

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|December 6, 2017
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Summary

Phase-sensitive surface plasmon resonance (SPR) biosensors offer superior sensitivity for real-time molecular interaction analysis. This review details advanced phase interrogation methods and future trends in SPR sensing technology.

Keywords:
ellipsometryheterodyneinterferometryphase detectionsurface plasmon resonance

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Area of Science:

  • Optics and Photonics
  • Biotechnology
  • Biosensing

Background:

  • Surface plasmon resonance (SPR) is a label-free optical sensing technique for monitoring molecular interactions.
  • SPR biosensors operate via angle, wavelength, intensity, or phase interrogation.
  • Phase-interrogated SPR sensors offer enhanced sensitivity and throughput, emerging as prominent biosensing devices.

Purpose of the Study:

  • To summarize the fundamentals of phase-sensitive SPR sensing.
  • To review existing methods for SPR phase interrogation.
  • To discuss future prospects and trends in phase-sensitive SPR technology.

Main Methods:

  • Review of literature on phase-sensitive SPR sensing.
  • Categorization of SPR biosensors based on interrogation principles.
  • Analysis of various phase interrogation techniques: heterodyne detection, polarimetry, shear interferometry, spatial/temporal phase modulation interferometry.

Main Results:

  • Phase-sensitive SPR offers high sensitivity and label-free monitoring of molecular interactions.
  • Multiple phase interrogation methods exist, each with unique advantages.
  • Emerging trends point towards increased sensitivity and throughput in SPR biosensing.

Conclusions:

  • Phase-sensitive SPR sensing is a rapidly advancing field with significant potential.
  • Further development of phase interrogation techniques will drive innovation in biosensing.
  • This technology is crucial for real-time, high-sensitivity molecular interaction studies.