Related Experiment Video

Updated: Feb 17, 2026

A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation
07:14

A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation

Published on: July 13, 2018

15.2K

Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity

Clare Pace1, Ruben Dagda2, Jeff Angermann3

  • 1Department of Environmental Science and Health, University of Nevada, Reno, NV 89557, USA. clare.pace@gmail.com.

Toxics
|December 6, 2017
PubMed

Insights

Antioxidants can reverse arsenic-induced cardiovascular damage by protecting mitochondria from oxidative stress. This research identifies 21 antioxidants with potential to improve heart health for those exposed to arsenic.

Area of Science:

  • Cardiovascular Toxicology
  • Mitochondrial Dysfunction
  • Oxidative Stress Research

Background:

  • Arsenic is a known cardiovascular toxicant and carcinogen.
  • Therapeutic arsenic compounds like arsenic trioxide cause severe cardiovascular side effects.
  • Arsenic toxicity is linked to mitochondrial dysfunction and oxidative stress.

Purpose of the Study:

  • To investigate the effectiveness of antioxidants against arsenic-induced cardiovascular dysfunction.
  • To identify antioxidants that can protect cardiovascular cells and tissues from arsenic toxicity.
  • To explore the potential of antioxidants in mitigating cardiovascular risks associated with arsenic exposure.

Main Methods:

  • Literature review identifying antioxidants with mito-protective properties.
  • Analysis of evidence for antioxidant efficacy in reversing mitochondrial dysfunction and oxidative stress.
  • Assessment of antioxidant potential in cardiovascular cells and tissues.

Main Results:

  • Identified 21 antioxidants capable of reversing mitochondrial dysfunction and oxidative stress.
  • Demonstrated that antioxidant phytonutrients can scavenge free radicals, ameliorating arsenic's toxic effects.
  • Highlighted the potential of these antioxidants to improve cardiovascular health in arsenic-exposed populations.

Conclusions:

  • Antioxidants show significant promise in combating arsenic-induced cardiovascular toxicity.
  • Further research is needed to enhance antioxidant bioavailability and targeted delivery for clinical application.
  • Developing novel mito-protective antioxidants could benefit millions exposed to arsenic through environmental or therapeutic sources.
Keywords:
antioxidantarsenic toxicitycardiovascularoxidative stresssuperoxide

More Related Videos

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish08:09

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

10.4K
Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.7K

Related Concept Videos

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.1K
The Electron Transport Chain01:30

The Electron Transport Chain

The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
20.4K
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
3.3K
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.4K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
20.7K
Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
24