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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

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[ASSOCIATION BETWEEN VERTEBRAL FRACTURES AND VASCULAR CALCIFICATIONS]

Giovanni Piscopo1, Luigi Morrone2

  • 1UOC Nefrologia, Dialisi e Trapianto, AOU Policlinico, Bari.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|December 6, 2017
PubMed

Insights

Bone fractures and abdominal aortic calcifications are linked, especially in chronic kidney disease patients. Identifying these conditions can help pinpoint individuals at higher cardiovascular risk for better treatment.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Orthopedics

Background:

  • Studies show a link between bone fractures and abdominal aortic calcifications (AAC).
  • This association persists independently of common risk factors like age, smoking, and diabetes.
  • Both conditions are prevalent in the general population and patients with chronic kidney disease (CKD).

Purpose of the Study:

  • To explore the association between bone fractures and AAC.
  • To investigate the clinical significance of this link, particularly in CKD patients.
  • To determine if identifying these conditions can aid in cardiovascular risk stratification.

Main Methods:

  • Review of cross-sectional and prospective studies.
  • Analysis of data considering confounders such as aging, smoking, and diabetes.
  • Focus on both general populations and CKD patient cohorts.

Main Results:

  • A significant association exists between bone fractures and severe AAC.
  • This link is observed in both general and CKD populations.
  • Both fractures and AAC correlate with increased cardiovascular morbidity and mortality.

Conclusions:

  • Bone fractures and AAC are indicators of heightened cardiovascular risk.
  • Screening for fractures and AAC, especially in CKD patients, can identify high-risk individuals.
  • This identification allows for optimized management of bone metabolism disorders and cardiovascular health.

Keywords:
Chronic Kidney DiseaseVertebral fracturesmortalityvascular calcifications

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