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Macrophage Cytoplasmic Transfer in Melanoma Invasion
Pakavarin Louphrasitthiphol1, Colin R Goding1
1Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Developmental Cell
|December 6, 2017
Abstract:
Within tumors, macrophage infiltration can promote cancer cell invasiveness and, consequently, metastatic dissemination. In this issue of Developmental Cell, Roh-Johnson et al. (2017) reveal that cytoplasmic transfer from macrophages to melanoma cells correlates with melanoma invasion and arises as a result of intimate cell-cell contact.
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