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Related Concept Videos

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish08:35

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Related Experiment Video

Updated: Jan 20, 2026

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish
08:35

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish

Published on: July 12, 2021

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Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study.

Jonghyuk Choi1, Sanghyuk Bae1, Hyungryul Lim1

  • 1Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea.

Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi
|December 6, 2017
PubMed
Summary
This summary is machine-generated.

Total mercury (Hg) exposure is linked to elevated gamma-glutamyltransferase (GGT) liver enzyme levels in Korean adults. Frequent alcohol consumption in women amplifies this association, increasing AST, ALT, and GGT.

Keywords:
Alanine transaminaseAspartate aminotransferasesGamma-glutamyltransferaseInteractionMercury

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Related Experiment Videos

Last Updated: Jan 20, 2026

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Area of Science:

  • Environmental Health
  • Toxicology
  • Hepatology

Background:

  • Mercury (Hg) is a known neurotoxin, but its impact on liver function is less understood.
  • Investigating mercury's effects on liver enzymes is crucial for public health, especially in potentially exposed populations.

Purpose of the Study:

  • To determine the association between total mercury (Hg) exposure and serum levels of liver enzymes (AST, ALT, GGT) in Korean adults.
  • To explore potential interactions between Hg exposure, alcohol consumption, and liver enzyme levels.

Main Methods:

  • Longitudinal study involving 508 Korean adults with repeated measurements of blood Hg and liver enzymes (2010-2015).
  • Statistical analysis included generalized linear models for cross-sectional associations and generalized additive mixed models for nonlinear relationships.
  • Generalized estimating equations were used to analyze longitudinal associations, accounting for repeated measures within individuals.

Main Results:

  • A significant positive association was observed between blood Hg levels and serum gamma-glutamyltransferase (GGT) in both men and women.
  • Aspartate aminotransferase (AST) and alanine transaminase (ALT) were not significantly associated with Hg levels overall.
  • In women with frequent alcohol consumption (>2-3 times/week), higher Hg levels were significantly associated with increased AST, ALT, and GGT, indicating an interaction effect.

Conclusions:

  • Mercury exposure is associated with elevated GGT levels in Korean adults.
  • The synergistic effect of mercury and alcohol consumption significantly increases AST, ALT, and GGT levels, particularly in women who drink frequently.
  • These findings highlight the importance of considering combined exposures in assessing liver health risks.