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Serum Uric Acid in Chronic Obstructive Pulmonary Disease: A Hospital Based Case Control Study
Rajlaxmi Sarangi1, Nirupama Varadhan2, Jyotirmayee Bahinipati3
1Associate Professor, Department of Biochemistry, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Journal of Clinical and Diagnostic Research : JCDR
|December 7, 2017
Summary
Serum uric acid (UA) levels are higher in Chronic Obstructive Pulmonary Disease (COPD) patients and correlate with disease duration. This simple test may aid in risk stratification for COPD patients.
Area of Science:
- Pulmonary Medicine
- Biochemistry
Background:
- Chronic Obstructive Pulmonary Disease (COPD) pathogenesis involves airway inflammation and oxidant/antioxidant imbalance.
- Previous research on serum uric acid (UA) in COPD has yielded conflicting results.
Purpose of the Study:
- To quantify serum UA levels in COPD patients.
- To investigate the correlation between serum UA levels and COPD duration and severity.
Main Methods:
- Serum UA levels were measured using an enzymatic colorimetric assay in 39 stable COPD patients and 46 controls.
- COPD staging followed Global Initiative for Obstructive Lung Disease (GOLD) criteria.
- Correlations were analyzed with disease duration, severity, smoking status, and alcohol intake.
Main Results:
- COPD patients exhibited significantly higher serum UA levels compared to controls (4.85±1.67 vs. 2.32±0.93 mg/dl).
- Hyperuricemia significantly correlated with longer COPD duration (≥ 10 years).
- Nonsmokers with COPD had higher UA levels than smokers; gender and alcohol intake showed no significant association.
Conclusions:
- Serum uric acid is a cost-effective biomarker for potential risk stratification in newly diagnosed COPD.
- Elevated uric acid levels are linked to advanced duration and stage of COPD.
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