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FOXA1 inhibits hepatocellular carcinoma progression by suppressing PIK3R1 expression in male patients

Shujiao He1,2, Junyi Zhang1,2, Wan Zhang1,2

  • 1Cancer Center, Southern Medical University, Guangzhou, Guangdong, 510315, China.

Journal of Experimental & Clinical Cancer Research : CR
|December 7, 2017
PubMed
Abstract

Insights

Forkhead box A1 (FOXA1) acts as a tumor suppressor in liver cancer (HCC). It inhibits the PI3K/Akt pathway by targeting PIK3R1, reducing cancer cell growth and movement in male patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Hepatocellular Carcinoma Research

Background:

  • Forkhead box A1 (FOXA1) is implicated in various cancers, but its specific role in hepatocellular carcinoma (HCC) is not well understood.
  • Understanding FOXA1's function is crucial for developing targeted therapies for liver cancer.

Purpose of the Study:

  • To elucidate the role and mechanism of FOXA1 in the development of hepatocellular carcinoma (HCC).
  • To identify FOXA1 target genes and their impact on HCC progression.

Main Methods:

  • Gene function gain and loss analyses were performed on HepG2 and Hep3B cell lines.
  • Clinical HCC samples were analyzed to correlate FOXA1 expression with patient outcomes.

Main Results:

  • Phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) was identified as a direct target gene of FOXA1.
  • FOXA1 suppresses HCC cell viability and motility by inhibiting the PI3K/Akt signaling pathway via PIK3R1 transcriptional repression.
  • Lower FOXA1 and higher PI3Kp85 expression were observed in tumor tissues of male HCC patients, with elevated PI3Kp85 indicating a poor prognosis.

Conclusions:

  • FOXA1 functions as a tumor suppressor in male HCC patients.
  • FOXA1 directly targets PIK3R1, inhibiting the PI3K/Akt pathway to suppress HCC proliferation, migration, and invasion.
Keywords:
FOXA1Hepatocellular carcinomaPI3K/AktPIK3R1/PI3Kp85

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