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Analysis of potential interactions between vitamins D and C using gene expression profiles from mouse models
Yan Jiao1, Mingming Niu2, Cheng Tian2
1Mudanjiang Medical College, Mudanjiang, 157001, HeilongJiang, PR China.
Cellular and Molecular Biology (Noisy-Le-Grand, France)
|December 7, 2017
Summary
This study explored molecular interactions between vitamin D (VD) and vitamin C (VC) using mouse gene expression. Findings reveal distinct but interconnected pathways, highlighting potential biases in animal models for human health research.
Area of Science:
- Nutritional Biochemistry
- Genomics
- Molecular Biology
Background:
- Vitamin D (VD) and vitamin C (VC) are vital nutrients for human health.
- Mouse models are frequently employed to study VD and VC, despite human C production differences.
Purpose of the Study:
- To investigate molecular-level interactions between VD and VC pathways.
- To analyze gene expression profiles related to the vitamin D receptor (Vdr) and gulonolactone oxidase (Lgo) in mice.
Main Methods:
- Utilized whole genome expression profiles from 111 mouse spleens and 40 mouse livers.
- Identified genes correlated with Vdr and Lgo.
- Analyzed molecular pathways and gene network connections between Vdr and Lgo.
Main Results:
- Vdr and Lgo associate with distinct gene sets, with some overlap.
- Gene network construction indicates interactions between Vdr and Lgo pathways.
- Identified specific genes linked to both Vdr and Lgo.
Conclusions:
- VD and VC pathways exhibit molecular interactions in mice.
- Results provide a foundation for future VD-VC interaction studies.
- Highlights potential limitations of mouse models for human VD/VC research due to species-specific VC synthesis.
