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Gadolinium deposition in the paediatric brain: T1-weighted hyperintensity within the dentate nucleus following

J R Young1, I Orosz2, M A Franke2

  • 1Department of Radiology, UC Davis School of Medicine, 4860 Y. Street, Suite #3100, Sacramento, CA 95817, USA; Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, 1621E, Los Angeles, CA 90095, USA.

Clinical Radiology
|December 7, 2017
PubMed

Insights

Repeated administration of gadolinium-based contrast agents (GBCAs) in children is linked to higher T1-weighted signal intensity in the dentate nucleus. This finding suggests a potential association between cumulative GBCA dose and signal changes in pediatric brain MRIs.

Area of Science:

  • Neuroradiology
  • Pediatric Imaging
  • Neuroscience

Background:

  • Gadolinium-based contrast agents (GBCAs) are widely used in MRI.
  • Concerns exist regarding the long-term effects of repeated GBCA administration, particularly in pediatric populations.
  • Previous studies have suggested gadolinium retention in the brain.

Purpose of the Study:

  • To investigate the association between repeated GBCA administration and T1-weighted signal intensity in the cerebellar dentate nucleus in children.
  • To determine if cumulative gadolinium dose correlates with signal changes in the dentate nucleus.

Main Methods:

  • Retrospective study of 41 pediatric patients (under 18) who received at least four brain MRIs between 2005 and 2015.
  • Calculation of the mean dentate nucleus-to-pons signal intensity (DN-P SI) ratio for each MRI.
  • Comparison of DN-P SI ratios from the first to the last MRI and correlation with cumulative gadolinium dose using a linear mixed-effects model.

Main Results:

  • A significant increase in the mean DN-P SI ratio was observed from the first to the last MRI examination (1.05 to 1.11, p=0.004).
  • A significant positive association was found between the DN-P SI ratio and cumulative gadolinium dose, even after controlling for confounding factors (coefficient=0.401, p=0.032).

Conclusions:

  • Repeated GBCA administration in children is associated with increased T1-weighted signal intensity in the dentate nucleus.
  • This suggests a potential link between cumulative gadolinium exposure and neuroimaging findings in pediatric patients.
Abstract

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