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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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How stable are antimicrobial susceptibility profiles in serial clinical isolates? A retrospective study informing repeat-testing strategies.

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Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
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Microbiologic factors affecting Clostridium difficile recurrence.

C H Chilton1, D S Pickering1, J Freeman2

  • 1Leeds Institute for Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|December 7, 2017
PubMed
Summary
This summary is machine-generated.

Recurrent Clostridium difficile infection (rCDI) is a significant healthcare challenge. Understanding the role of the gut microbiome and microbial factors is crucial for developing effective treatments and preventing reinfection.

Keywords:
Antimicrobial persistenceClostridium difficileIntestinal microbiotaRecurrenceSpores

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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Area of Science:

  • Microbiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Recurrent Clostridium difficile infection (rCDI) imposes a substantial economic and practical burden on healthcare systems.
  • rCDI significantly impacts patients' quality of life, often leading to a cycle of infection and reliance on antibiotics.
  • Risk factors for rCDI are similar to initial Clostridium difficile infection (CDI) and include immune status, comorbidities, and treatments.

Purpose of the Study:

  • To discuss the critical role of microbiologic factors in the development of recurrent Clostridium difficile infection (rCDI).

Main Methods:

  • A literature search was conducted on PubMed for articles published from 2000 onwards using the search term 'recurrent Clostridium difficile infection'.
  • Additional relevant references were identified from the bibliographies of the initially selected articles.

Main Results:

  • Poor bacterial diversity in the gut is correlated with clinical rCDI.
  • The presence of viable C. difficile spores is essential for rCDI, influenced by gut environmental factors like dysbiosis.
  • Emerging treatments include narrow-spectrum antimicrobials and microbiota therapeutics such as fecal microbiota transplantation.

Conclusions:

  • Addressing rCDI requires a multifaceted strategy encompassing infection control, C. difficile-targeted antibiotics to minimize gut dysbiosis, and gut microflora restoration.
  • Understanding the interplay between C. difficile and the gut microbiome is key to effective rCDI management.
  • Restoring colonization resistance through microbiome modulation is a promising approach for preventing rCDI.