Correlation between benzene and testosterone in workers exposed to urban pollution
M V Rosati1, A Sancini2, F Tomei2
1Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Specialty School of Occupational Medicine, Unit of Occupational Medicine, University of Rome "Sapienza", Rome.
La Clinica Terapeutica
|December 7, 2017
Summary
Occupational exposure to benzene may lower testosterone levels. This study found a link between benzene metabolites in urine and reduced free testosterone, particularly at lower benzene exposure levels.
Area of Science:
- Environmental Health
- Endocrinology
Background:
- Benzene exposure is a concern in occupational and urban environments.
- Previous research indicates potential effects of benzene on testosterone, but further investigation is needed.
Purpose of the Study:
- To investigate the correlation between blood benzene levels and testosterone levels.
- To assess the relationship between benzene metabolites and testosterone in exposed workers.
Main Methods:
- 148 subjects provided blood samples for benzene and testosterone analysis.
- Urine analysis measured trans, trans-muconic acid and S-phenylmercapturic acid.
- Pearson correlation and multiple linear regression were used to analyze data.
Main Results:
- A significant inverse correlation was observed between S-phenylmercapturic acid and free testosterone.
- Trans-trans muconic acid showed a significant direct correlation with BMI.
- Lower benzene exposure levels showed a stronger inverse correlation between S-phenylmercapturic acid and free testosterone.
Conclusions:
- Preliminary findings suggest occupational benzene exposure may impact testosterone levels.
- Further research is required to confirm these results and explore fertility implications.
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