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1Institut für Pathologie, 3. Medizinische Fakultät, Karls-Universität, Universitätskrankenhaus Kralovske Vinohrady, Šrobárova 1150/50, 10034, Prag, Tschechien. jan.hrudka@gmail.com.
Der Pathologe
|December 7, 2017
Summary
A rare case of kidney cancer was found to be a metastasis from lung cancer. This highlights the importance of thorough histopathological examination for accurate diagnosis of renal tumors.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Renal cell carcinoma (RCC) is a common kidney malignancy.
- Metastatic disease to the kidney can mimic primary renal tumors.
- Accurate diagnosis is crucial for appropriate patient management.
Observation:
- A 65-year-old man presented with hematuria and neurological symptoms, with suspected kidney tumor and metastases.
- Cytoreductive nephrectomy revealed clear cell renal cell carcinoma (RCC).
- An unexpected focus of high-grade adenocarcinoma was identified as a metastasis from a poorly differentiated lung adenocarcinoma.
Findings:
- Histopathological examination confirmed clear cell RCC alongside a metastatic lung adenocarcinoma.
- Immunohistochemistry, including positive TTF1 and napsin-A staining, supported the lung origin.
- This case illustrates a rare tumor-in-tumor metastasis phenomenon.
Implications:
- This case underscores the importance of comprehensive histopathological evaluation and immunohistochemistry in diagnosing renal masses.
- Differential diagnosis of poorly differentiated kidney adenocarcinoma should include metastatic disease, particularly from lung primary.
- Understanding tumor-in-tumor metastasis is vital for accurate staging and treatment planning in oncology.
