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[Two synchronous malignancies in a single nephrectomy specimen].

J Hrudka1, V Eis2, J Šach2

  • 1Institut für Pathologie, 3. Medizinische Fakultät, Karls-Universität, Universitätskrankenhaus Kralovske Vinohrady, Šrobárova 1150/50, 10034, Prag, Tschechien. jan.hrudka@gmail.com.

Der Pathologe
|December 7, 2017
PubMed
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This summary is machine-generated.

A rare case of kidney cancer was found to be a metastasis from lung cancer. This highlights the importance of thorough histopathological examination for accurate diagnosis of renal tumors.

Area of Science:

  • Oncology
  • Pathology
  • Urology

Background:

  • Renal cell carcinoma (RCC) is a common kidney malignancy.
  • Metastatic disease to the kidney can mimic primary renal tumors.
  • Accurate diagnosis is crucial for appropriate patient management.

Observation:

  • A 65-year-old man presented with hematuria and neurological symptoms, with suspected kidney tumor and metastases.
  • Cytoreductive nephrectomy revealed clear cell renal cell carcinoma (RCC).
  • An unexpected focus of high-grade adenocarcinoma was identified as a metastasis from a poorly differentiated lung adenocarcinoma.

Findings:

  • Histopathological examination confirmed clear cell RCC alongside a metastatic lung adenocarcinoma.
  • Immunohistochemistry, including positive TTF1 and napsin-A staining, supported the lung origin.
Keywords:
AdenocarcinomaKidney adenocarcinomaKidney tumourMetastasisNephrectomy

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  • This case illustrates a rare tumor-in-tumor metastasis phenomenon.

    • Implications:

    • This case underscores the importance of comprehensive histopathological evaluation and immunohistochemistry in diagnosing renal masses.
    • Differential diagnosis of poorly differentiated kidney adenocarcinoma should include metastatic disease, particularly from lung primary.
    • Understanding tumor-in-tumor metastasis is vital for accurate staging and treatment planning in oncology.