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Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
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Related Experiment Video

Updated: Feb 17, 2026

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
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[Chondroblastoma].

G Jundt1, D Baumhoer2

  • 1Knochentumor-Referenzzentrum und DÖSAK-Zentralregister am Institut für Pathologie, Universitätsspital Basel, Schoenbeinstraße 40, 4031, Basel, Schweiz. gernot.jundt@unibas.ch.

Der Pathologe
|December 7, 2017
PubMed
Summary
This summary is machine-generated.

Chondroblastomas are rare bone tumors in children, often diagnosed by imaging and H3F3B gene mutation. Thorough curettage is the recommended treatment, even for recurrences.

Keywords:
Bone neoplasmsChondroblastomaEpiphysesImmunohistochemistryPoint mutation

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Area of Science:

  • Orthopedic Oncology
  • Pediatric Bone Tumors
  • Skeletal Radiology

Background:

  • Chondroblastomas are rare, benign primary bone tumors.
  • They predominantly affect the epiphyses/apophyses of long bones in pediatric patients.
  • Typical imaging and histological findings aid diagnosis.

Purpose of the Study:

  • To summarize the key aspects of chondroblastomas.
  • To highlight diagnostic methods, including genetic markers.
  • To discuss treatment and prognosis.

Main Methods:

  • Review of typical clinical presentation.
  • Analysis of histopathological features.
  • Genetic analysis (H3F3B gene mutation p.K36M) via sequencing or immunohistochemistry.
  • Evaluation of treatment outcomes and recurrence rates.

Main Results:

  • Diagnosis is often straightforward due to characteristic findings.
  • The H3F3B gene mutation (p.K36M) is a highly specific diagnostic marker.
  • Recurrence rates range from 5-15%; lung metastases are rare (<1%).
  • Histologically 'malignant' chondroblastomas are exceptionally rare.

Conclusions:

  • Chondroblastomas are rare benign bone tumors in adolescents.
  • Genetic confirmation (H3F3B p.K36M) supports typical diagnostic findings.
  • Complete surgical curettage is the primary treatment, effective for local relapses.