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A mathematical model of recurrent spreading depolarizations
Cameron Conte1, Ray Lee1, Monica Sarkar1
1Department of Mathematics, Ohio State University, Columbus, OH, USA.
Journal of Computational Neuroscience
|December 7, 2017
Summary
This study presents a biophysical model of neuron/astrocyte networks to investigate cortical spreading depolarizations. It reveals the roles of glutamate and potassium in the initiation and spread of these events.
Area of Science:
- Neuroscience
- Computational Biology
- Biophysics
Background:
- Cortical spreading depolarizations (CSDs) are waves of neural activity implicated in neurological disorders.
- Previous models lacked detailed biophysical mechanisms for CSD initiation and propagation.
Purpose of the Study:
- To develop a detailed biophysical model of neuron-astrocyte networks.
- To explore the mechanisms underlying the initiation, propagation, and recurrence of CSDs.
- To investigate the specific roles of extracellular glutamate and potassium (K+) in CSDs.
Main Methods:
- Development of a detailed biophysical model of a neuron/astrocyte network.
- Incorporation of a model for the sodium-glutamate transporter to describe reverse glutamate uptake.
- Simulation of CSDs under conditions of elevated extracellular glutamate and K+.
Main Results:
- The model successfully simulates the initiation, propagation, and recurrence of CSDs.
- Elevated extracellular glutamate and K+ were identified as key factors in CSD dynamics.
- The model provides a detailed description of reverse glutamate uptake's role.
Conclusions:
- The developed biophysical model offers new insights into CSD mechanisms.
- Extracellular glutamate and K+ play critical roles in the initiation, propagation, and recurrence of CSDs.
- The model advances our understanding of neuronal network behavior during CSDs.
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