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Published on: May 22, 2018
Differential Modulating Effect of MoS2 on Amyloid Peptide Assemblies
Jie Wang1,2, Lei Liu1, Daohan Ge3
1Institute for Advanced Materials, Jiangsu University, 212013 Xuefu Road No. 301, Zhenjiang city, Jinagsu Province, P.R. China.
Abstract:
The abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two-dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label-free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS2 presents different modulating effects on the assembly of amyloid-β peptide (33-42) [Aβ (33-42)] and amylin (20-29), mainly owing to the distinct affinity between amyloid peptides and MoS2 . This is to our knowledge the first report of MoS2 as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self-assembly of amyloid peptides, and expands the applications of MoS2 in biology.
Insights
Molybdenum disulfide (MoS2) modulates amyloid peptide aggregation, offering new insights into amyloid diseases. This study is the first to report MoS2
Area of Science:
- Biomaterials Science
- Nanotechnology
- Neuroscience
Background:
- Amyloid diseases are linked to abnormal amyloid fibril formation.
- Modulating amyloid assembly is crucial for understanding disease pathogenesis.
- Two-dimensional nanomaterials like graphene oxide and tungsten disulfide show promise in modulating amyloid fibrillogenesis.
Purpose of the Study:
- To investigate the modulation effect of molybdenum disulfide (MoS2) on the self-assembly of amyloid peptides.
- To explore the distinct interactions between MoS2 and different amyloid peptides.
Main Methods:
- Label-free techniques including quartz crystal microbalance (QCM), atomic force microscopy (AFM), and circular dichroism (CD) spectroscopy were employed.
- The study focused on amyloid-beta peptide (33-42) [Aβ(33-42)] and amylin (20-29).
Main Results:
- Molybdenum disulfide (MoS2) demonstrated varying modulation effects on the assembly of Aβ(33-42) and amylin (20-29).
- These differential effects are attributed to distinct binding affinities between the amyloid peptides and MoS2.
- This marks the first report of MoS2 acting as a modulator for amyloid aggregation.
Conclusions:
- MoS2 is a novel nanomaterial modulator for amyloid fibrillogenesis.
- Understanding MoS2's interaction with amyloid peptides sheds light on disease mechanisms.
- This research expands the biological applications of MoS2 and enriches the field of 2D nanomodulators.
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