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Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion.

Bob Smit1, Yvo M Smulders2, Etto C Eringa3

  • 1Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands.

Microcirculation (New York, N.Y. : 1994)
|December 7, 2017
PubMed
Summary

Breathing higher oxygen levels did not change oxygen delivery (DO2) but did decrease microvascular flow in healthy individuals. Significant hemodynamic changes were not observed until arterial oxygen tension exceeded 20 kPa.

Keywords:
dose responsehealthy volunteershyperoxiamicrocirculationoxygenoxygen delivery

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Area of Science:

  • Physiology
  • Microcirculation Research
  • Oxygen Physiology

Background:

  • Understanding the effects of hyperoxia on human physiology is crucial.
  • The dose-response relationship between arterial oxygen tension and microcirculatory function requires further elucidation.

Purpose of the Study:

  • To investigate the human dose-response relationship between increasing arterial oxygen tension and its effects on oxygen delivery (DO2) and sublingual microcirculatory perfusion.
  • To identify thresholds for hemodynamic and microcirculatory changes during hyperoxia.

Main Methods:

  • Fifteen healthy volunteers inhaled increasing oxygen fractions to achieve target arterial oxygen tensions.
  • Systemic hemodynamics were continuously monitored using the volume-clamp method.
  • Sublingual microcirculation was assessed using sidestream darkfield (SDF) imaging.

Main Results:

  • Systemic oxygen delivery (DO2) remained unchanged across all tested oxygen tensions.
  • Peripheral vascular داله (PVD) decreased in a dose-dependent, sigmoidal manner, with a maximum reduction of 15% during maximal oxygen breathing.
  • Cardiac index (CI) decreased linearly by a maximum of 10%, primarily due to a heart rate reduction, with most changes observed above 20 kPa.

Conclusions:

  • Supraphysiological arterial oxygen tensions do not impact systemic DO2 in healthy individuals.
  • Sublingual microcirculatory PVD exhibits a dose-dependent decrease with increasing arterial oxygen tension.
  • Hemodynamic alterations are minimal at arterial oxygen tensions up to 20 kPa.