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Related Experiment Video

Updated: Feb 17, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Current and future therapeutic approaches for osteosarcoma.

Douglas J Harrison¹, David S Geller², Jonathan D Gill¹

¹a Department of Pediatrics , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Expert Review of Anticancer Therapy

|December 7, 2017

Summary

This summary is machine-generated.

Current osteosarcoma treatments offer limited survival benefits, especially for metastatic or recurrent cases. Novel therapeutic strategies and research into the tumor

Keywords:

Osteosarcoma adjuvant chemotherapy and cisplatin (MAP)doxorubicin limb-salvage methotrexate muramyl tripeptide phosphatidylethanolamine (MTP-PE)neoadjuvant chemotherapy

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Last Updated: Feb 17, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Area of Science:

Orthopedic Oncology
Medical Oncology
Translational Research

Background:

Current osteosarcoma treatment involves surgery and chemotherapy, achieving ~70% 5-year event-free survival (EFS) for localized disease.
Outcomes for metastatic or recurrent osteosarcoma remain poor, with <20% overall survival.
A plateau in survival rates necessitates novel research approaches.

Purpose of the Study:

To review current and future treatment strategies for osteosarcoma.
To highlight promising novel agents, surgical techniques, and ongoing clinical trials.

Main Methods:

Comprehensive literature search of PubMed.
Detailed review of recent clinical trials and innovative research.
Analysis of preclinical data for novel therapeutic agents.

Main Results:

Limited improvement in osteosarcoma patient outcomes over several decades.
Ongoing Phase II studies show promise for novel agents based on preclinical data.
Interest in evaluating novel agents in high-risk recurrent osteosarcoma populations.

Conclusions:

Novel therapeutic approaches are urgently needed for osteosarcoma.
Further research into the genetic and immunological profiles of osteosarcoma is crucial.
Identifying novel pathways and targets will be essential for future treatment development.