Related Experiment Video
Updated: Feb 17, 2026
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
A Newly Synthetized Ferrocenyl Derivative Selectively Induces Apoptosis in ALL Lymphocytes through Mitochondrial
Marjan Aghvami1, Jalal Pourahmad1, Afshin Zarghi1
1Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background:
Estrogens, as the main female steroid hormones have multiple proven effects on reproductive and non- reproductive systems. Expression of ERα and ERβ, two dominant estrogen receptors, in peripheral blood mononuclear cells in certain B-cell malignancies and the existence of estrogens receptors on mitochondria is open to question that estrogen likely has an impact on the cancerous lymphocytes life span. Acute Lymphoblastic Leukemia (ALL) is the frequent pediatric malignity which is recurrent and hardly curable in many cases. The malignant cells are generally resistant to apoptosis caused the severe lymphocytes accumulation in the peripheral blood.
Methods:
By focusing on mitochondria as a life/death center of the cell; in the current research we compared cytotoxicity effects of a new ferrocenyl derivative with raloxifene as well-known SERMs considering the apoptotic process and survival of cancerous lymphocytes.
Results:
We demonstrated that both ferrocenyl derivative and raloxifene could cause mitochondrial lesion and initiate the apoptosis process by caspase activation and cytochrome c release.
Conclusion:
In brief, the ferrocenyl derivative could induce estrogen-related selective apoptosis on cancerous lymphocytes by affecting mitochondrial receptors.
Insights
A novel ferrocenyl derivative selectively induces cancer cell death in Acute Lymphoblastic Leukemia (ALL) by targeting mitochondrial estrogen receptors. This compound initiates apoptosis, offering a potential new therapeutic strategy for this challenging pediatric malignancy.
Area of Science:
- Endocrinology
- Cancer Biology
- Pharmacology
Background:
- Estrogens, primarily female steroid hormones, influence reproductive and non-reproductive systems.
- Estrogen receptors (ERα and ERβ) expression in B-cell malignancies and on mitochondria suggests a role in cancerous lymphocyte lifespan.
- Acute Lymphoblastic Leukemia (ALL), a common pediatric malignancy, is often recurrent and difficult to treat due to apoptosis-resistant malignant cells.
Purpose of the Study:
- To investigate the cytotoxic effects of a new ferrocenyl derivative compared to raloxifene (a SERM) on cancerous lymphocytes.
- To evaluate the impact of these compounds on mitochondrial function, apoptosis, and lymphocyte survival.
Main Methods:
- Mitochondria were targeted as the cell's life/death center.
- Cytotoxicity of a novel ferrocenyl derivative and raloxifene was compared.
- Apoptotic processes and cancerous lymphocyte survival were assessed.
Main Results:
- Both the ferrocenyl derivative and raloxifene induced mitochondrial damage.
- Apoptosis was initiated via caspase activation and cytochrome c release.
- The ferrocenyl derivative demonstrated estrogen-related selective apoptosis in cancerous lymphocytes.
Conclusions:
- The ferrocenyl derivative selectively induces apoptosis in cancerous lymphocytes by interacting with mitochondrial estrogen receptors.
- This compound shows potential as a therapeutic agent for Acute Lymphoblastic Leukemia by targeting cancer cell mitochondria.
More Related Videos
19:44Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
Published on: May 30, 2012
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Related Concept Videos
01:16Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
01:17The Extrinsic Apoptotic Pathway
01:31Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
01:30Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
01:31The Intrinsic Apoptotic Pathway
01:30Apoptosis