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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Oral cancer stem cells - properties and consequences
Camila Oliveira Rodini1, Nathália Martins Lopes1, Vanessa Soares Lara2
1Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Bauru, SP, Brasil.
Journal of Applied Oral Science : Revista FOB
|December 7, 2017
Summary
Cancer stem cells (CSCs) are often confused with normal stem cells (SCs), especially in dentistry. This review clarifies CSCs and their role in oral cancer development, metastasis, and treatment resistance.
Area of Science:
- Biomedical Sciences
- Oncology
- Stem Cell Biology
Background:
- Cancer stem cells (CSCs) research is expanding, but conceptual misunderstandings persist.
- CSCs are frequently misidentified as normal stem cells (SCs).
- In dentistry, oral CSCs are often confused with normal tooth-derived SCs.
Purpose of the Study:
- To clarify the concepts of normal stem cells (SCs) and cancer stem cells (CSCs).
- To differentiate between SCs and CSCs, particularly in the oral context.
- To discuss the significance of CSCs in oral squamous cell carcinoma (OSCC).
Main Methods:
- Literature review.
- Conceptual clarification of stem cell terminology.
- Analysis of CSCs' role in OSCC pathogenesis.
Main Results:
- Distinction between normal SCs and CSCs is crucial.
- Oral CSCs are distinct from normal tooth-derived SCs.
- CSCs are implicated in OSCC development, metastasis, and therapy resistance.
Conclusions:
- Accurate understanding of CSCs is vital for advancing cancer research and treatment.
- Clarifying CSC concepts, especially in dentistry, is necessary.
- CSCs are key drivers of oral squamous cell carcinoma progression and therapeutic challenges.
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