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Drug-induced meningitis

Jeffrey G Wong, Sharon C Hathaway, John J Paat

    Postgraduate Medicine
    |December 7, 2017
    PubMed

    Insights

    Drug-induced aseptic meningitis is a rare side effect of certain medications. This report details a case involving trimethoprim-sulfamethoxazole and reviews its potential mechanisms and clinical features.

    Area of Science:

    • Pharmacology
    • Neurology
    • Toxicology

    Background:

    • Drug-induced aseptic meningitis (DIAM) is an uncommon adverse drug reaction.
    • Various medications have been implicated in the development of DIAM.
    • Understanding the mechanisms and clinical presentation is crucial for diagnosis.

    Purpose of the Study:

    • To present a case of DIAM associated with trimethoprim-sulfamethoxazole.
    • To review the proposed mechanisms of DIAM.
    • To discuss the clinical presentation and course of DIAM.

    Main Methods:

    • Case report presentation.
    • Literature review of proposed mechanisms for DIAM.
    • Summary of clinical features and patient outcomes.

    Main Results:

    • A case of aseptic meningitis linked to trimethoprim-sulfamethoxazole use is described.
    • Multiple potential mechanisms for drug-induced meningitis are discussed.
    • Typical clinical signs and the disorder's progression are outlined.

    Conclusions:

    • Trimethoprim-sulfamethoxazole can cause aseptic meningitis.
    • DIAM is a complex condition with various underlying mechanisms.
    • Awareness of DIAM is important for clinicians managing patients on certain medications.

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