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Updated: Feb 17, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and
Edward Allan Racela Sison1, Peter Kurre2, Yong-Mi Kim3
1a Department of Pediatrics, Texas Children's Cancer and Hematology Centers , Baylor College of Medicine , Houston , Texas , USA.
Abstract:
Signaling between leukemia cells and nonhematopoietic cells in the bone marrow microenvironment contributes to leukemia cell growth and survival. This complicated extrinsic mechanism of chemotherapy resistance relies on a number of pathways and factors, some of which have yet to be determined. Research on cell-cell crosstalk the bone marrow microenvironment in acute leukemia was presented at the 2016 annual Therapeutic Advances in Childhood Leukemia (TACL) investigator meeting. This review summarizes the mini-symposium proceedings and focuses on chemokine signaling via the cell surface receptor CXCR4, adhesion molecule signaling via integrin α4, and crosstalk between leukemia cells and the bone marrow microenvironment that is mediated through extracellular vesicles.
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