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Oncogene-Driven Metabolic Alterations in Cancer.
Hye-Young Min1,2, Ho-Young Lee1,2,3
1Creative Research Initiative Center for concurrent control of emphysema and lung cancer, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Biomolecules & Therapeutics
|December 8, 2017
Summary
Cancer cells rewire their metabolism to fuel rapid growth and survival. Targeting these metabolic changes offers a promising strategy for developing novel cancer therapies, especially for difficult-to-treat cancers.
Area of Science:
- Oncology
- Cancer Biology
- Metabolic Pathways
Background:
- Cancer is a leading global cause of death, necessitating research into its fundamental biology.
- Beyond genetic mutations, cancer cells exhibit significant metabolic reprogramming to meet high energy and biosynthesis demands.
- This metabolic rewiring, including aerobic glycolysis and altered nutrient utilization, is crucial for cancer progression and tumor-microenvironment interactions.
Purpose of the Study:
- To review recent findings on metabolic rewiring in cancer.
- To explore the link between oncogenic alterations and metabolic reprogramming.
- To discuss therapeutic strategies targeting cancer metabolism, with a focus on lung cancer.
Main Methods:
- Literature review of recent studies on cancer metabolism.
- Analysis of the association between oncogenic mutations and metabolic changes.
- Evaluation of preclinical and clinical data on metabolic inhibitors in cancer treatment.
Main Results:
- Cancer cells exhibit diverse metabolic adaptations, including aerobic glycolysis and dependency on specific nutrients like glutamine.
- Oncogenic mutations are strongly linked to cancer's metabolic reprogramming.
- Metabolic alterations influence the tumor microenvironment and cancer progression.
Conclusions:
- Metabolic reprogramming is a hallmark of cancer, essential for its growth and survival.
- Targeting cancer metabolism presents a viable therapeutic avenue, particularly for cancers with intractable oncogenic drivers like KRAS.
- Further research into cancer metabolic pathways can lead to innovative treatment strategies for various cancers, including lung cancer.
Keywords:
Aerobic glycolysisCancerCancer metabolismMetabolic reprogrammingNon-small cell lung cancerOncogenic alterationMore Related Videos
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