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Enhanced anticancer potency by thermo/pH-responsive PCL-based magnetic nanoparticles.

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Journal of Biomaterials Science. Polymer Edition
|December 8, 2017
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This study developed a novel stimuli-responsive nanocarrier for co-delivering doxorubicin (DOX) and methotrexate (MTX). The nanocarrier demonstrated enhanced antitumor activity and reduced toxicity compared to free drugs.

Keywords:
Combination chemotherapyapoptosisbiodegradablemagnetic nanocompositepoly caprolactonetargeted delivery

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Combination therapies show promise for synergistic effects in cancer treatment.
  • Developing predictable drug carriers is crucial for effective therapeutic responses.
  • Stimuli-responsive nanocarriers offer targeted drug delivery advantages.

Purpose of the Study:

  • To develop a stimuli-responsive paramagnetic nanocarrier for co-delivery of doxorubicin (DOX) and methotrexate (MTX).
  • To investigate the intracellular delivery and efficacy of the nanocarrier in MCF7 cell lines.
  • To evaluate the antitumor activity and cytotoxicity of the dual-drug loaded nanocarrier.

Main Methods:

  • Synthesis of a thermo/pH-sensitive amphiphilic paramagnetic nanocomposite using ring opening and free radical polymerization.
  • Physicochemical characterization using FTIR, HNMR, CNMR, SEM, EDX, TGA, and VSM.
  • Evaluation of drug encapsulation efficiency, in vitro drug release, and antitumor activity (MTT assay, DAPI staining, cell cycle, real-time PCR).

Main Results:

  • High encapsulation efficiency for both DOX (95.04%) and MTX (97.29%).
  • Tumor niche-specific drug release observed at 41°C and pH ≤ 5.4.
  • Significantly enhanced antitumor activity and reduced toxicity of the DOX/MTX-loaded nanocarrier compared to free drugs in MCF7 cells.

Conclusions:

  • The developed nanocarrier is suitable for anticancer drug delivery.
  • This engineered dual-drug delivery system enhances antitumor efficacy.
  • The nanocarrier system offers potential for reduced systemic toxicity in cancer therapy.