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Hypertriglyceridemia and atherosclerosis

Jia Peng1, Fei Luo1, Guiyun Ruan1

  • 1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Lipids in Health and Disease
|December 8, 2017
PubMed

Insights

High triglycerides (TG) are linked to increased atherosclerotic cardiovascular disease (ASCVD) risk, but the exact mechanism is unclear. This review examines clinical studies and TG

Area of Science:

  • Cardiology
  • Biochemistry
  • Epidemiology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality worldwide.
  • Elevated low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for atherosclerosis.
  • Emerging evidence highlights a significant association between hypertriglyceridemia and increased ASCVD risk.

Purpose of the Study:

  • To review current clinical studies investigating the link between hypertriglyceridemia and ASCVD.
  • To elucidate the proatherogenic mechanisms by which triglycerides (TG) contribute to atherosclerosis.
  • To provide a comprehensive reference for the prevention and treatment strategies of ASCVD in the context of hypertriglyceridemia.

Main Methods:

  • Systematic review of clinical research on hypertriglyceridemia and ASCVD.
  • Analysis of preclinical and clinical data on triglyceride metabolism and atherogenesis.
  • Synthesis of evidence regarding the molecular and cellular mechanisms involved in TG-induced atherosclerosis.

Main Results:

  • Hypertriglyceridemia is increasingly recognized as an independent risk factor for ASCVD.
  • Several proatherogenic mechanisms of triglycerides are being elucidated, including remnant particle formation and inflammation.
  • The precise role of TG in the development and progression of atherosclerosis requires further investigation.

Conclusions:

  • Hypertriglyceridemia represents a significant, yet often underestimated, risk factor for ASCVD.
  • Understanding the proatherogenic pathways of TG is crucial for developing targeted therapies.
  • Further research is warranted to fully clarify the mechanisms and optimize the management of hypertriglyceridemia for ASCVD prevention.

Keywords:
AtherosclerosisAtherosclerotic cardiovascular diseaseLipoproteinTriglyceride

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