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Related Concept Videos

Long-term Potentiation01:25

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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Long-term Potentiation01:35

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:05

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Neuroplasticity01:01

Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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Related Experiment Video

Updated: Feb 17, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

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Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells.

Sven Berberich1,2, Jörg Pohle1,3, Marie Pollard2,4

  • 1Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J 5, 68159, Mannheim, Germany.

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|December 8, 2017
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Summary

Synaptic plasticity in hippocampal neurons shows pathway-specific changes. Different stimulation patterns alter synaptic competition and network stability, revealing asymmetric plasticity mechanisms.

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Paired Whole Cell Recordings in Organotypic Hippocampal Slices
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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Synaptic Plasticity

Background:

  • Information storage mechanisms involve global and pathway-specific synaptic plasticity.
  • Interactions between these plasticity forms in enhancing synaptic competition and network stability are not well understood.

Purpose of the Study:

  • To investigate the interplay between apical and basal dendritic synaptic plasticity in CA1 pyramidal neurons.
  • To uncover how different stimulation protocols influence synaptic competition and neuronal excitability.

Main Methods:

  • Electrophysiological recordings in mouse hippocampal slices.
  • Stimulation protocols involving bursts of action potentials (AP-bursts) and presynaptic stimulation.
  • Pharmacological manipulation targeting L-type voltage-gated Ca2+ channels, NMDA, and adenosine receptors.

Main Results:

  • Timing-dependent long-term potentiation (LTP) varied with age and stimulation frequency.
  • Shortening the pre-post delay selectively potentiated the paired pathway, while unpaired pathways showed complex potentiation or depression.
  • Asymmetric plasticity was observed, with specific ion channels and receptors mediating differential pathway potentiation.

Conclusions:

  • Synaptic plasticity in hippocampal CA1 neurons exhibits pathway-specific and asymmetric properties.
  • These findings provide insights into how synaptic efficacy and neuronal excitability are modulated for distinct information pathways.