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Rationale for launching a new journa.

Ricardo Nitrini1

  • 1Editor-in-Chief.

Dementia & Neuropsychologia
|December 8, 2017
PubMed
Summary

Understanding vascular dementia requires knowing brain anatomy and cholinergic pathways. Strategic lesion locations impacting these pathways explain cognitive decline and guide treatments targeting cholinergic activity.

Area of Science:

  • Neuroscience
  • Vascular Neurology
  • Cognitive Science

Background:

  • Vascular cognitive impairment/dementia (VCI/VD) is prevalent, with significant therapeutic potential.
  • Cerebral vascular territories and anatomy are crucial for understanding VCI/VD manifestations.
  • The central cholinergic system modulates cognition, behavior, and cerebral blood flow.

Discussion:

  • Mapping cholinergic pathways, including basal prosencephalon nuclei and projections, is key.
  • Integrating vascular and cholinergic pathway anatomy identifies critical lesion sites.
  • Vascular lesions interrupting cholinergic pathways cause denervation and hypofunction.

Key Insights:

  • Strategic vascular lesion localization in relation to cholinergic pathways is vital for VCI/VD.
Keywords:
anatomycholinergic fiberscognitive impairmentvascular dementia

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  • Understanding these anatomical correlations enhances clinical evaluation of VCI/VD.
  • This knowledge provides a foundation for treatments aimed at boosting cholinergic activity.

    • Outlook:

    • Further research into precise vascular-cholinergic interactions can refine VCI/VD diagnosis.
    • Developing targeted therapies based on these anatomical insights holds promise.
    • Improved understanding may lead to novel preventive and compensatory strategies for VCI/VD.