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Updated: Feb 17, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Subcortical ischemic vascular disease and cognition: A systematic review
Gilberto Sousa Alves1, Carlos Eduardo de Oliveira Alves1, Maria Elisa Lanna1
1Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil.
Abstract:
Subcortical Ischemic Vascular Disease (SIVD) is underdiagnosed. This review investigates the relationship among SIVD severity, cognitive status and neuroimaging markers.
Methods:
Cohort, cross-sectional and case control studies were searched on ISI, Medline, Scielo, PsychoInfo and LILACS databases published between 1995 and 2006.
Results:
The most impaired cognitive domains were executive, attentional and memory retrieval mechanisms. These cognitive features were frequently associated to White Matter Lesions (WML).
Conclusions:
WML is an independent factor in cognitive decline. However, the threshold for this impact is not yet clearly established.
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