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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

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Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Updated: Feb 17, 2026

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
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Does prevention for Alzheimer's disease exist?

Sonia Maria Dozzi Brucki1

  • 1MD, PhD, Neurologist from the Cognitive and Behavioral Neurology Group (University of São Paulo); Psychobiology Department (Federal University of São Paulo); Hospital Santa Marcelina, São Paulo, SP, Brazil.

Dementia & Neuropsychologia
|December 8, 2017
PubMed
Summary
This summary is machine-generated.

Preventing Alzheimer's disease is crucial. A healthy lifestyle, including physical activity, social engagement, and managing vascular risks, may help delay dementia onset.

Keywords:
Alzheimer’s diseasecholinesterase inhibitorsnutritionphysical exercisepreventionstatins

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Area of Science:

  • Neuroscience
  • Public Health
  • Gerontology

Background:

  • Alzheimer's disease prevention is a significant public health challenge due to the aging population.
  • Currently, no effective curative treatments exist, making prevention strategies vital for reducing healthcare costs.

Purpose of the Study:

  • To review potential preventive factors for Alzheimer's disease.
  • To explore both lifestyle modifications and pharmacological approaches for Alzheimer's disease prevention.

Main Methods:

  • A literature review was conducted.
  • Reports were selected from PubMed using keywords 'Alzheimer's disease' and 'prevention'.

Main Results:

  • Healthy lifestyle choices, including physical, cognitive, and leisure activities, are associated with delayed dementia.
  • Good social engagement, a diet rich in fish and moderate in wine, low dietary fat intake, and controlled vascular risk factors show potential for prevention.

Conclusions:

  • Pursuing a healthy lifestyle and managing vascular risk factors are key potential strategies for delaying Alzheimer's disease.
  • Further research into preventive measures is warranted given the lack of curative treatments.