Related Experiment Video

Updated: Feb 17, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

13.9K

Systemic Treatment of Metastatic Conjunctival Melanoma

Simão Pinto Torres1, Teresa André2, Emanuel Gouveia2

  • 1Department of Medical Oncology, Hospital Professor Doutor Fernando Fonseca E.P.E., 2720-276 Amadora, Portugal.

Case Reports in Oncological Medicine
|December 8, 2017
PubMed

Insights

Conjunctival melanoma (CM) is a rare cancer that often recurs. Novel systemic therapies, like checkpoint inhibitors and BRAF/MEK targeted treatments, show promise for advanced CM, similar to cutaneous melanoma.

Area of Science:

  • Ophthalmology
  • Oncology
  • Genetics

Background:

  • Conjunctival melanoma (CM) is an exceptionally rare malignancy.
  • CM has a high propensity for local and distant recurrence, with common metastatic sites including lungs, skin, liver, and brain.

Observation:

  • Recent advancements in systemic treatments, including checkpoint inhibitors and targeted therapies (BRAF/MEK), have significantly improved care for advanced and metastatic melanoma.
  • While CM patients are often excluded from clinical trials, its molecular and genetic similarities to cutaneous melanoma suggest potential efficacy of these novel agents.

Findings:

  • The authors present two rare cases of metastatic conjunctival melanoma with unique genetic profiles.
  • These distinct genetic profiles led to the patients receiving different systemic treatment regimens.

Implications:

  • These cases highlight the potential for novel systemic therapies in managing metastatic conjunctival melanoma.
  • Further research into the molecular drivers and treatment responses in CM is warranted to optimize patient outcomes.

More Related Videos

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

2.2K
Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development06:46

Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development

Published on: September 4, 2021

1.8K

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.4K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.2K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K