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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

21
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Related Experiment Video

Updated: Feb 17, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

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New trends in anaphylaxis.

Margitta Worm1, Gunter Sturm2, Jörg Kleine-Tebbe3

  • 1Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Allergo Journal International
|December 8, 2017
PubMed
Summary
This summary is machine-generated.

Anaphylaxis management trends show increased adrenaline use and improved diagnostics for insect venom allergies. While immunotherapy shows promise, further research on training and rare triggers is needed.

Keywords:
AnaphylaxisEducation food allergyEmergency careHymenoptera venom allergyMolecular diagnostics

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Anaphylaxis remains a significant health concern with identifiable common and rare triggers.
  • Management strategies and diagnostic approaches are continually evolving.

Purpose of the Study:

  • To review current trends in anaphylaxis management based on the 4th International Network for Online-Registration of Anaphylaxis (NORA) conference.
  • To highlight advancements in diagnostics, treatment adherence, and awareness.

Main Methods:

  • Review of data from the NORA anaphylaxis registry.
  • Meta-analysis of insect venom anaphylaxis trends.
  • Survey on guideline implementation.
  • Analysis of case reports and awareness studies.

Main Results:

  • Hymenoptera venom, foods, and drugs are common anaphylaxis triggers; rare triggers include chicory, cardamom, asparagus, and goji berries.
  • Insect venom immunotherapy may prevent severe reactions and improve quality of life, with improved diagnostic accuracy via molecular diagnostics.
  • Adrenaline use increased from 23% to 29% (2012-2016), indicating better guideline adherence.
  • Component-resolved diagnostics aid in assessing severe reaction risk.

Conclusions:

  • Adherence to anaphylaxis management guidelines is improving, with increased epinephrine use.
  • Advanced diagnostics and potential immunotherapy offer better patient outcomes.
  • Further research is necessary for optimizing anaphylaxis awareness training and understanding rare triggers.