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Microfluidics in Assessing Platelet Function
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TRAF3 negatively regulates platelet activation and thrombosis

Rui Zhang1,2, Guoying Zhang1, Binggang Xiang1

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, University of Kentucky, 741 South Limestone Street, Lexington, KY, 40536, USA.

Scientific Reports
|December 8, 2017
PubMed
Summary

Tumor necrosis factor superfamily member CD40 ligand (CD40L) interacts with CD40. TRAF3 negatively regulates platelet activation and thrombus formation, as demonstrated by increased aggregation and accelerated thrombus development in TRAF3 knockout mice.

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