Evolutionary analysis of mumps viruses of genotype F collected in mainland China in 2001-2015

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Aili Cui1, Pierre Rivailler1,2, Zhen Zhu1

  • 1WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, No. 155, Changbai Road, Changping District, Beijing, 102206, People's Republic of China.

Scientific Reports
|December 8, 2017
PubMed

Insights

Mumps virus genotype F in China shows rapid evolution in its SH gene. This genotype, prevalent for 20 years, originated around 1980 and spread from northern provinces.

Area of Science:

  • Virology
  • Epidemiology
  • Molecular Evolution

Background:

  • Mumps incidence remains high in mainland China.
  • Genotype F has been the predominant mumps virus (MuV) genotype for two decades.
  • Understanding MuV genetic diversity is crucial for public health.

Purpose of the Study:

  • To analyze the genetic characteristics of genotype F MuV strains in China from 2001-2015.
  • To determine evolutionary rates and phylogeography of genotype F MuV.
  • To provide baseline genetic data for mumps prevention and control.

Main Methods:

  • Sequencing of Small Hydrophobic (SH), Hemagglutinin-Neuraminidase (HN), and Fusion (F) genes of MuV.
  • Phylogenetic analysis to determine evolutionary rates and common ancestry.
  • Phylogeographic analysis to trace viral spread patterns.

Main Results:

  • The SH gene exhibited an evolutionary rate three times faster than HN and F genes.
  • The most recent common ancestor of genotype F MuV was estimated to be around 1980.
  • Four distinct lineages were identified within HN and F gene sequences.
  • Genotype F viruses likely originated in Liaoning and Shandong provinces and spread south and east.

Conclusions:

  • The rapid evolution of the SH gene may influence mumps virus adaptation and transmission.
  • The identified lineages and spread patterns provide insights into mumps epidemiology in China.
  • This genetic data is vital for developing effective mumps control strategies.

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