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[Current status of vascular remodeling and angiogenesis in chronic liver diseases]

A S Batyrova, M I Bakanov, A N Surkov

    Patologicheskaia Fiziologiia I Eksperimental'Naia Terapiia
    |December 8, 2017
    PubMed

    Insights

    Researchers analyzed liver and mesenteric vascular pathophysiology and angiogenesis in chronic liver disease (CLD). Soluble vascular endothelial growth factor receptors are key for prognosis and treating CLD-related angiogenesis disorders.

    Area of Science:

    • Vascular biology
    • Hepatology
    • Pathophysiology

    Background:

    • Chronic liver disease (CLD) involves complex vascular alterations.
    • Understanding angiogenesis is crucial for CLD progression and treatment.
    • Mesenteric and hepatic vascular beds are significantly affected in CLD.

    Purpose of the Study:

    • To review current research on the pathophysiology of the liver vascular bed and mesenteric vessels.
    • To analyze the characteristics of angiogenesis in CLD.
    • To highlight key molecular targets for CLD treatment.

    Main Methods:

    • Comprehensive literature review of studies on CLD pathophysiology.
    • Analysis of research focusing on angiogenesis in liver disease.
    • Evaluation of data on vascular endothelial growth factor receptors.

    Main Results:

    • Significant alterations in the pathophysiology of the liver vascular bed and mesenteric vessels in CLD.
    • Angiogenesis plays a critical role in the development and progression of CLD.
    • Soluble vascular endothelial growth factor receptors (sVEGFRs) are identified as crucial biomarkers.

    Conclusions:

    • Soluble vascular endothelial growth factor receptors are vital for predicting prognosis and guiding treatment in CLD.
    • Targeting sVEGFRs may offer a therapeutic strategy for managing angiogenesis disorders in CLD.
    • Further research into sVEGFRs is warranted for effective CLD management.

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