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Published on: September 4, 2016
Mortality Among Hardmetal Production Workers: The Swedish Cohort
Håkan Westberg1, Ing-Liss Bryngelsson, Gary Marsh
1Department of Occupational and Environmental Medicine, Faculty of Science, Örebro University, Örebro, Sweden (Dr Westberg, Ms Bryngelsson); Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania (Dr Marsh, Dr Buchanich, Ms Zimmerman); Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois (Ms Kennedy, Dr Esmen); and Department of Medical Science, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden (Dr Svartengren).
Background:
The mortality pattern was determined in a cohort of 16,999 white and blue-collar workers in the Swedish hardmetal industry, particularly for cobalt exposure and lung cancer.
Methods:
The mortality follow-up analysis in the Swedish Mortality register covered the period from 1952 to 2012. The exposure measures were ever/never exposed, duration of exposure, cumulative, and mean cobalt concentrations.
Results:
The mortality of all causes was significantly increased, highly associated with the short-term employed workers. A negative exposure-response was found for lung cancer and duration of exposure. An exposure-response was determined for cumulative and mean cobalt exposures analyzed by quartiles, but not for exposure classes. Internal comparison analysis using proportional hazard showed no exposure-response.
Conclusions:
The cohort lung cancer mortality showed no correlation to cobalt, nickel, or tungsten exposure.
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